Flotillin family protein
WebFlotillin-1 Antibody detects endogenous levels of total flotillin-1 protein. Species Reactivity: Human, Mouse, Rat, Monkey. ... Flotillins belong to a family of lipid raft-associated integral membrane proteins that carry an … WebOct 20, 2024 · For FLOT1-/FLOT2-positive early endosomes, we identify >300 putative cargo proteins and confirm eleven substrates for flotillin-dependent endocytosis, including the latrophilin family of adhesion ...
Flotillin family protein
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WebBackground & aims: The flotillin family of proteins, including flotillin-1 (FLOT1 or Reggie-2), are lipid raft proteins that initiate receptor kinase signaling and are up-regulated in several tumor types. We investigated the role of FLOT1 signaling and activation of the transcription factor nuclear factor (NF)-κB in esophageal squamous cell carcinoma … WebOct 1, 2005 · The flotillin family is composed of two highly homologous proteins, flotillin 1 and flotillin 2, characterized by the presence of a prohibitin homology (PHB) domain, which is responsible for ...
WebNov 28, 2024 · The flotillin family is composed of two highly homologous members: flotillin-1 (flot-1 or reggie-2) and flotillin-2 (flot-2 or reggie-1) 12. Both members of the family are ubiquitously expressed ... WebMar 1, 2008 · The flotillin-2 protein induction was observed as early as 12 hours after TAp73β or TAp63γ overexpression. Even when Saos-2 cells were infected with Ad-p53 at a MOI of 100, flotillin-2 was not significantly induced by p53 (Fig. 3B, ... Here, we present a novel target of the p53 family members, flotillin-2, a major protein on lipid rafts.
WebDec 15, 2014 · Flotillin 2 is a target gene of p63 and p73, members of the p53 transcription factor family (Sasaki et al., 2008). Flotillin promoters are activated by mitogen-activated protein kinase (MAPK) signaling, retinoic acid treatment and expression of various transcription factors (Banning et al., 2012). Flotillin 1 expression is also negatively ... WebFlotillin 2 is a direct transcriptional target of the p53 family member genes in human cancer cells. The interaction of flotillin-2 with amyloid precursor protein (APP) promotes the clustering of APP at the cell surface. Coassembly of flotillin1 and flotillin2 into microdomains induces membrane curvature, the formation of plasma-membrane ...
WebApr 1, 2009 · Flotillin-1 (FLOT1 or reggie-2) and flotillin-2 (FLOT2 or reggie-1) are ubiquitously expressed proteins in mammalian cells (Babuke and Tikkanen, 2007).They are approximately 50% identical in their amino acid sequence, and belong to a large family of proteins containing a stomatin-prohibitin-flotillin-HflK/C (SPFH) domain, a motif that is …
Webanalysis of the cDNA for this protein has provided new avenues by which to explore the structure and function of caveolae organelles. Interestingly, flotillin is a close homologue … naviland truckingWebMay 24, 2016 · Flotillin-1 (Flot1, reggie-2) is a lipid raft-associated scaffolding protein that belongs to a family of proteins characterized by an evolutionarily conserved SPFH domain (Browman et al., 2007; Langhorst et al., 2008).Although flotillin-1 is ubiquitously expressed, it is known to be highly expressed in brain tissue, and has been shown to serve distinct … naviland teatroWebSep 18, 2012 · The family of flotillin proteins consists of two homologous members, flotillin-1 and flotillin-2, also termed “reggies”, with flotillin-1 being identical to reggie-2 … markets bu programmatic freewheelWebThe flotillin (reggie) like proteins are lipid raft-associated. Individual proteins of this SPFH family may cluster to form membrane microdomains which may in turn recruit … naviks of ny incWebNov 27, 2009 · Calcium spiking appears to control activity of a calcium/calmodulin-dependent protein kinase and two downstream GRAS-family transcription factors, NSP1 and NSP2, which interact in the plant nucleus and directly bind the ... which contains the protein flotillin . Flotillins [also called Reggies (11)] are often used as markers for ... naviland trackingWebDuring Hepatitis C virus (HCV) morphogenesis, the non-structural protein 2 (NS2) brings the envelope proteins 1 and 2 (E1, E2), NS3, and NS5A together to form a complex at the endoplasmic reticulum (ER) membrane, initiating HCV assembly. The nature of the interactions in this complex is unclear, but replication complex and structural proteins … markets by 1937 benbow st covina caWebApr 13, 2024 · Patellins, a protein family that has PI-binding activity, have been identified in plant-derived EVs, providing a basis for this hypothesis that requires future investigation. FCW = fungal cell wall, FM = fungal membrane, FMT = fungal memtub, FLOT/REM = flotillin/remorin, LE = late endosome, PCW = plant cell wall, PATL = patellin, PS = … navila es show